ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome.

ABSTRACT:

Background

Ajmaline challenge (AC) is used for diagnosing suspected Brugada syndrome (BS) in patients with unexplained syncope, survived cardiac arrest, or for family screening.

Purpose

To evaluate baseline ECG markers predicting a positive AC in the absence of a spontaneous diagnostic Brugada ECG.

Methods

Baseline ECGs of 221 consecutive patients undergoing AC (up to 1 mg/kg bodyweight) were analyzed. ECGs from positive and negative tests were compared, with Q-, R-, S-, J-, and T-wave amplitudes and intervals measured in all 12 leads.

Results

221 patients underwent AC; the cohort was 71% male, and 7% had survived cardiac arrest. AC was positive in 93 patients (42%). Prominent S-waves in lead II and J-waves in V1 predicted a positive AC (S-wave duration: 36 vs.

SUBMITTER: Tulumen E 

PROVIDER: S-EPMC12683172 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature