Graphene-Enhanced Plasmonic Interfaces: A General Strategy for Highly Sensitive Detection of Biomolecular Interactions.

ABSTRACT: The detection of cells and viruses is essential for research and clinical applications, creating a demand for high-performance biosensors. Surface plasmon resonance (SPR) enables label-free, real-time detection and is highly promising for healthcare, including point-of-care diagnostics. However, its performance is often limited in complex biological systems. Integrating two-dimensional (2D) materials such as graphene into SPR sensors has been proposed as a strategy to improve sensitivity, but experimental evidence remains scarce. Here, we investigate the influence of graphene on SPR biosensors using several relevant biological examples, including antibody-virus and peptide-cell interactions. Compared to gold sensors, graphene integration produced reproducible signal enhancement of up to 60

SUBMITTER: Hasnain A 

PROVIDER: S-EPMC12683200 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature