Nitric Oxide-Releasing Catheters with Phenol-Amine Catalytic Coatings for Improved Anti-Inflammatory Performance.

ABSTRACT: Nitric oxide (NO) is a signaling molecule critical for vasodilation, bacterial inhibition, and inflammation modulation, making it valuable for medical devices, such as catheters. However, existing NO-releasing catheters face challenges, including maintaining stable NO release over time and complex manufacturing processes. In this study, a robust nanocoating made from tannic acid (TA) and selenocystamine (SeCA) is presented, designed to catalytically generate NO from S-nitrosoglutathione in the presence of glutathione. Surface characterization techniques confirmed successful coating formation, with optimal NO generation achieved at a 1:4 TA:SeCA molar ratio. The coated catheters maintained over 96% viability of human coronary artery smooth muscle cells (HCASMCs) after 72 h. It has been demo

SUBMITTER: Fan Q 

PROVIDER: S-EPMC12683202 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature