ROS-Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing.

ABSTRACT: Chronic wounds often experience delayed healing due to a disrupted microenvironment marked by persistent inflammation and excessive fibrosiswhich leads to tissue dysfunction. Excessive mitochondrial reactive oxygen species (ROS) at the injury siteworsen this by hindering healing and promoting scarring. This study presents a multifunctional microneedle array (MNA) that combines ROS scavenging with accelerated tissue formation. The array contains Flightless I (Flii) siRNA-loaded arginine-functionalized poly (β-amino ester)-alginate (APA) particles within a hyaluronic acid methacrylate (HaMA) matrix. These siRNA-APA particles enhance ROS scavenging through nitric oxide (NO) delivery and silence Flii expression in HaCaT cells. The synergistic release of NO, arginine, and siRNA reduces pro-infl

SUBMITTER: Kharaziha M 

PROVIDER: S-EPMC12683203 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature