Novel Drug-Testing Platform for Vascular Injury-induced Intimal Hyperplasia Using a Microphysiological System.

ABSTRACT: Drug-coated balloons (DCBs) and drug-eluting stents (DESs) with antiproliferative drugs have been developed to prevent restenosis. However, some patients who undergo DCB or DES procedures still experience restenosis. Therefore, it is essential to explore therapeutic agents for DCBs and DESs. Furthermore, alternative platforms addressing current experimental model limitations are necessary for disease research. Here, a 3D model of vascular injury-induced intimal hyperplasia is developed by using a microphysiological system (MPS). This model effectively replicated the endothelial denudation, proliferation, and migration of vascular smooth muscle cells (VSMCs), and vascular inflammation associated with the disease. Using this disease model, it is shown that antiproliferative drugs suppress VS

SUBMITTER: Nam U 

PROVIDER: S-EPMC12683234 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature