Effects of <i>Angelica archangelica</i> Extract on Overactive Bladder: A Pilot Randomized Controlled Trial.

ABSTRACT: Overactive bladder (OAB) is a prevalent syndrome affecting quality of life (QoL) in 10.8% of men and 12.8% of women in Europe, impacting various aspects of daily functioning. Conventional treatments like antimuscarinic drugs show low adherence due to limited efficacy and side effects. This study explores the effects of natural supplementation with Angelica archangelica (AA) leaf extract on OAB symptoms, focusing on daytime voids, nocturia, and urgency. A pilot study with a randomized, triple-blind, controlled trial design, registered on ClinicalTrials.gov (NCT04357223), was conducted with 143 participants assigned to AA (SUP) or placebo (PLA) groups in a 1.75:1 ratio over 6 weeks. Adults aged 18-75 with specific OAB symptoms were included. Data were securely managed via the RedCap p

SUBMITTER: Lopez-Seoane J 

PROVIDER: S-EPMC12683295 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature