Motor performance and higher associative cortical networks in adolescents with neonatal hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia.

ABSTRACT:

Aim

To investigate the interaction between specialized motor networks and higher associative brain networks for motor performance in adolescents exposed to neonatal hypoxic-ischaemic encephalopathy (HIE).

Method

In this prospective, population-based cohort study of children (n = 66) with neonatal HIE treated with therapeutic hypothermia, follow-up was performed at age 10 to 12 years with resting-state functional magnetic resonance imaging and assessment of motor performance with the Movement Assessment Battery for Children, Second Edition (MABC-2). Brain-behaviour analysis was performed using statistical enrichment analysis and was compared to a control group (n = 43) using the McNemar test.

Results

The final analysis included 35 children in the cohort with HIE (mean

SUBMITTER: Hakansson G 

PROVIDER: S-EPMC12683310 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature