Effects of Methylglyoxal on Intestinal Cells: Insights on Epigenetic Regulatory Enzymes.

ABSTRACT: Methylglyoxal (MGO) is endogenously produced under physiological conditions as a by-product of glycolysis and by autooxidation of glucose and lipid peroxidation. The digestive system can also take up MGO from exogenous sources, especially from ultra-processed foods. MGO is a highly reactive molecule, able to react with macromolecules forming covalent adducts resulting in advanced glycation end-products formation. MGO can also enter the nucleus and react with nucleic acids with the formation of MGO-nucleic acid adducts. The intestinal epithelium is continuously exposed to dietary and endogenous stimuli, including MGO, but the potential harmful role of MGO at the intestinal level has been poorly investigated. Therefore, the aim of the study was to further investigate the effects of MGO in in

SUBMITTER: Morresi C 

PROVIDER: S-EPMC12683318 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature