Composition of the maternal gastrointestinal microbiome as a predictor of neonatal birth weight.

ABSTRACT:

Background

The biological mechanism by which the maternal gastrointestinal microbiota contributes to fetal growth and neonatal birth weight is currently unknown. The purpose of this study was to explore how the composition of the maternal microbiome in varying pre-gravid body mass index (BMI) groups are associated with neonatal birth weight adjusted for gestational age.

Methods

Retrospective, cross-sectional metagenomic analysis of bio-banked fecal swab biospecimens (n = 102) self-collected by participants in the late second trimester of pregnancy.

Results

Through high-dimensional regression analysis using principal components (PC) of the microbiome, we found that the best performing multivariate model explained 22.9% of the variation in neonatal weight adjusted for g

SUBMITTER: Dreisbach C 

PROVIDER: S-EPMC12683343 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature