Exosomal biomarkers and therapeutics in lung cancer: a narrative review on their role in early detection and targeted treatment.

ABSTRACT:

Background and objective

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis and therapy resistance. Despite advances in targeted therapies and immunotherapies, the prognosis remains poor. There is a critical need for minimally invasive biomarkers that enable early detection, prognostic stratification and therapeutic monitoring. Exosomes, a subtype of extracellular vesicles, have emerged as promising candidates in this context given their role in intercellular communication and their selective cargo, which reflects the molecular state of tumor cells. This review aims to summarize the current evidence on the potential of exosomes and their cargo, particularly microRNAs (miRNAs), as diagnostic and prognostic biomarkers as w

SUBMITTER: Rodriguez-Sanz J 

PROVIDER: S-EPMC12683418 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature