A narrative review of pathologic response in non-small cell lung cancer: challenges, implications, and future directions.

ABSTRACT:

Background and objective

The increasing use of neoadjuvant therapy in non-small cell lung cancer (NSCLC) has magnified the importance of pathologic response as a treatment endpoint. However, there are persistent challenges in its assessment and interpretation. This review aimed to synthesize current methods and challenges in evaluating pathologic response in patients with NSCLC, summarize available assessment techniques and biomarkers, and collate current data on pathologic response to neoadjuvant treatments and the association with survival outcomes.

Methods

We selected and reviewed articles proposing guidelines or approaches to the pathologic assessment of NSCLC, articles describing challenges in assessing pathologic response in NSCLC, and studies reporting pathologic resp

SUBMITTER: Li Y 

PROVIDER: S-EPMC12683421 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature