Migrasome-related long non-coding RNAs orchestrate immune microenvironment and serve as a novel prognostic model in clear cell renal cell carcinoma.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) represents the most common histological subtype of kidney cancer and constitutes a major global health burden. Despite increasing recognition of the roles of migrasome-related long non-coding RNAs (MRLs) in tumor biology, their prognostic relevance in ccRCC remains largely undefined. Therefore, this study aimed to systematically identify MRLs associated with ccRCC prognosis and construct a robust prognostic model to improve risk stratification and guide potential therapeutic strategies.

Methods

To identify MRLs, we initially performed a correlation analysis integrating transcriptomic profiles with clinical parameters of ccRCC patients from The Cancer Genome Atlas (TCGA). Leveraging the expression matrix of MRLs, we subsequen

SUBMITTER: Huang J 

PROVIDER: S-EPMC12683443 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature