Integrative modeling of longitudinal cell-free DNA and tumor volume dynamics: a multimodal quantitative prognostic framework.

ABSTRACT:

Background

Liquid biopsy based on cell-free DNA (cfDNA) in oncology has emerged as a promising technique for tracking cancer dynamics, especially for detecting minimal residual disease. To date, most studies have used cfDNA for static evaluations of tumor burden. In this study, we propose a novel approach integrating serial cfDNA and computed tomography (CT) tumor volume to fully reflect the dynamic nature of tumor response after treatment.

Methods

This prospective study involved 25 patients treated with curative-intent radiotherapy for localized non-small cell lung cancer (NSCLC) between June 2019 and November 2020, with 17 subsequently included in final analysis. Longitudinal blood samples were divided into two phases relative to day 3 after treatment initiation, and kinet

SUBMITTER: Choi J 

PROVIDER: S-EPMC12683446 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature