7,8-dihydroxyflavone attenuates NIH IIIA subtype chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) via TrkB/AKT/SIRT3 signaling activation.

ABSTRACT:

Background

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) represents a prevalent urological disorder characterized by an unfavorable prognosis. Accumulating evidence indicates that suppression of excessive reactive oxygen species (ROS) generation significantly ameliorates its inflammatory manifestations. 7,8-dihydroxyflavone (7,8-DHF), a specific TrkB receptor agonist, which could subsequently trigger downstream signaling pathways such as AKT, demonstrates antioxidant and anti-inflammatory properties across diverse pathological conditions. Nevertheless, its potential therapeutic efficacy against CP/CPPS remains undefined. The aim of this study is to investigate the effects of 7,8-DHF on CP/CPPS and elucidate the underlying mechanisms involved, thereby providing fundamen

SUBMITTER: Li W 

PROVIDER: S-EPMC12683490 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature