Acrolein-triggered atherosclerosis <i>via</i> AMPK/SIRT1-CLOCK/BMAL1 pathway and a protection from intermittent fasting.

ABSTRACT: Circadian clock plays a vital role in the pathological progression of cardiovascular disease (CVD). Our previous studies showed that acrolein, an environmental pollutant, promoted atherosclerosis by reducing CLOCK/BMAL1 and disturbing circadian rhythm. Whereas, intermittent fasting (IF), a diet pattern, was able to ameliorate acrolein-induced atherosclerosis. In vivo, mice were fed acrolein 3 mg/kg/day via drinking water and IF for 18h (0:00-18:00). We observed that IF decreased acrolein-accelerated the formation of aortic lesion in ApoE ^-/- mice. Up-regulation of NF-κB, IL-1β and TNF-α levels were found in liver and heart tissue upon acrolein exposure, while was down-regulated by IF. Interestingly, IF treatment exhibited higher AMPK, p-AMPK an

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12683512 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature