A randomized, double-blinded, placebo-controlled study to evaluate the efficacy and safety of venlafaxine extended release in Japanese patients with generalized anxiety disorder.

ABSTRACT:

Aim

The current study investigated the superiority of anxiolytic effects of venlafaxine extended release (ER) compared with placebo and its safety and tolerability in Japanese adult outpatients with generalized anxiety disorder (GAD).

Methods

In this placebo-controlled, double-blind study, 357 eligible participants were randomized to receive venlafaxine ER (75-225 mg/day) or placebo for 8 weeks. The primary endpoint was change from baseline to week 8 in Hamilton Anxiety Rating Scale (HAM-A) total score. Secondary endpoints included changes from baseline to week 8 in scores of HAM-A psychic anxiety factors, HAM-A somatic anxiety factors, Clinical Global Impressions-Severity of Illness (CGI-S), Generalized Anxiety Disorder-7 (GAD-7), Zung Self-Rating Anxiety Scale (Z-SAS), She

SUBMITTER: Otsubo T 

PROVIDER: S-EPMC12683617 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature