Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta-analysis.

ABSTRACT: Schizophrenia is a complex psychiatric disorder characterized by positive, negative, and general psychopathological symptoms. While antipsychotic drugs are effective for positive symptoms, they provide limited benefit for negative symptoms, which are often persistent and strongly associated with functional disability. Additionally, up to 30% of patients exhibit resistance to current treatments, including clozapine. These challenges underscore the need for novel adjunctive strategies. This systematic review and meta-analysis, preregistered in PROSPERO (CRD42022359199), evaluated the efficacy and safety of repurposed antihypertensive drugs (AHTs) as adjunctive treatments for schizophrenia. PubMed, Web of Science, and Scopus were searched for double-blind, randomized controlled trials (RCTs)

SUBMITTER: Carnaval T 

PROVIDER: S-EPMC12683620 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature