Design and synthesis of coumarin-based pyrazole-pyrazoline hybrid derivatives and their photophysical, antimicrobial, sensing and computational studies.

ABSTRACT: In recent times, nitrogen-containing multi-heterocyclic compounds have emerged as valuable scaffolds in the field of medication development because of their broad spectrum of biological activities. In this context, we designed and synthesized new multi-heterocyclic coumarin-based pyrazole-pyrazoline hybrids (4a-4r) through a molecular hybridization approach. The green metrics assessment results revealed that the current molecular hybridization approach is environmentally benign and provides excellent green certification for a safe and sustainable environment. After successful structural characterization, all compounds were evaluated for their antimicrobial potential against various microbial strains. The results of antimicrobial studies showed that compound 4c was most active against B.

SUBMITTER: Sharma N 

PROVIDER: S-EPMC12683658 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature