Impact of Antibiotic Exposure on Pediatric Drug Eruption: A Nationwide Cohort Study in Korea.

ABSTRACT:

Purpose

Antibiotic-related drug eruption is a common cutaneous adverse reaction in pediatric populations. However, its incidence and risk factor remain unclear. This study investigated the incidence of drug eruptions in pediatrics and its association with antibiotic exposure to identify potential risk factors.

Methods

Using the Health Insurance Review and Assessment Service-Pediatric Patient Sample database (2009-2019), we conducted a retrospective nationwide cohort study involving 6,699,010 pediatric patients. Drug eruptions were identified based on administrative claims data using the International Classification of Diseases, 10th Revision codes L27.0 and L27.1. The incidence was compared between antibiotic-exposed and unexposed groups.

Results

We analyzed 4,107,522

SUBMITTER: Jeon SM 

PROVIDER: S-EPMC12683757 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature