EnsembleAge clock: a reliable and robust epigenetic age clock service reveals epigenetic age acceleration in opioid-overdosed brains.

ABSTRACT: Age is a major risk factor for various diseases, such as cancer, cardiovascular conditions, and neurodegenerative diseases. However, chronological age, the simple number of years one has lived, does not capture individual health differences, prompting the development of methods to accurately estimate biological age instead of relying on chronological age. One of the major molecular approaches exploits DNA methylation (DNAm), which is an essential epigenetic modifier for regulating gene expression, cell differentiation, and aging. DNAm-based aging clocks have been developed to predict biological age, but the prediction is highly dependent on training data, including organs and assay technologies. To address these clocks' high variance, we present two EnsembleAge clocks, leveraging eight pre

SUBMITTER: Anand A 

PROVIDER: S-EPMC12683782 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature