Efficacy based on dose-response and safety of bone marrow-derived mesenchymal stem cells for the treatment of osteoarthritis: a systematic review and meta-analysis.

ABSTRACT:

Introduction

In recent years, the use of mesenchymal stem cells (MSCs), especially those derived from bone marrow and embryonic sources, has been considered as an emerging therapeutic approach for repairing joint tissue and reducing osteoarthritis symptoms. This systematic review and meta-analysis evaluated bone marrow-derived mesenchymal stem cells (BM-MSCs) efficacy, safety, and optimal dosing for osteoarthritis treatment.

Methods

Thirteen randomized trials of the 1427 articles identified (11 meta-analyzed; n = 1150 patients) were identified via PubMed, Scopus, Embase, and other databases (search updated to May 2025). The primary outcomes were the optimal dose of BM-MSCs in improving pain intensity (VAS), WOMAC scores (pain, stiffness, function, total score), and their saf

SUBMITTER: Lohrasbi E 

PROVIDER: S-EPMC12683818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature