Integrative multi-omics reveals common and distinct pathogenic mechanisms and preoperative diagnostic signatures in breast fibroepithelial lesions.

ABSTRACT: Breast fibroepithelial lesions (FELs) comprising fibroadenomas (FAs) and phyllodes tumors (PTs) with varying degrees of malignancy, necessitate tailored surgical approaches. However, preoperative diagnosis of FELs remains challenging and their pathogenesis is not fully elucidated. By integrating methylation and expression data, we revealed substantial molecular deregulation common to FAs and PTs, impacting pathways central to genetic information processing and metabolism. Furthermore, we identified 86 genes exhibiting concurrent differential expression and methylation changes between FAs and PTs, some of which have been implicated in the malignant progression of disease. Subsequently, we constructed two gene-pair signatures: one comprising 158 pairs for distinguishing FAs from PTs, and ano

SUBMITTER: He M 

PROVIDER: S-EPMC12683819 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature