Gut mucosa-associated microbiota signatures in healthy individuals and patients at different stages of liver disease: a pilot study.

ABSTRACT:

Background

The gut microbiota plays a key role in the progression of chronic liver disease and the development of hepatocellular carcinoma (HCC). However, findings on microbiota composition in such patients remain inconsistent, likely due to differences in disease aetiology and sample type. The mucosa-associated microbiota (MAM), residing in the intestinal mucin layer, more accurately reflects mucosal health than faecal microbiota, being more stable and less influenced by diet. This study aimed to characterise the ileal and sigmoid MAM in patients with chronic hepatitis C (CHC), liver cirrhosis (LC), and HCC.

Methods

We performed DNA metabarcoding sequencing of mucosa samples collected from the ileum and sigmoid colon of patients at different stages of liver disease and heal

SUBMITTER: Compare D 

PROVIDER: S-EPMC12683826 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature