Patients with inflammatory bowel disease exhibit increased susceptibility to HCoV-NL63.

ABSTRACT: Immunocompromised inflammatory bowel disease (IBD) patients may develop life-threatening pneumonia and bronchiolitis upon HCoV-NL63 infection. However, little is known whether these patients will be more susceptible to HCoV-NL63 infection. We compared the expression of ACE2 in different tissues and cell lines. Besides, the susceptibility of colonic cells to HCoV-NL63 was assessed. We then examined the expression of ACE2 in the colonic mucosa from IBD patients and animal models, and in the inflammatory colonic cells. The susceptibility of inflammatory colonic cells to HCoV-NL63 was detected using a pseudovirus-based system. Pseudovirus based neutralization assay was used to quantify the neutralizing antibodies to HCoV-NL63 in patients with IBD and healthy controls. ACE2 was abundantly expre

SUBMITTER: Ning T 

PROVIDER: S-EPMC12683868 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature