Umbilical cord mesenchymal stem cells protect against obstetric deep venous thrombosis in rats by suppressing ferroptosis.

ABSTRACT:

Background

The objective of the current investigation is to explore the role of ferroptosis in mediating the protective effects associated with umbilical cord mesenchymal stem cells (UCMSCs) on obstetric deep venous thrombosis (DVT) in vivo and in vitro.

Methods

A pregnant rat model of DVT was created through the application of a "stenosis" technique targeting the inferior vena cava (IVC). Furthermore, the protective effects of UCMSCs were evaluated on pregnant rats with DVT and impaired endothelial cells. Subsequently, transcriptome sequencing was utilized to pinpoint the genes that exhibited differential expression in the thrombosed IVC tissues of rats belonging to both the DVT) and DVT + UCMSC groups. Finally, the role of the candidate gene was demonstrated.

Results

SUBMITTER: Cheng X 

PROVIDER: S-EPMC12683888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature