Distribution and dynamics of motile immune cells near the inner limiting membrane in the living human eye.

ABSTRACT: Recent attention has been given to immune cells near the inner limiting membrane (ILM) of the retina due to their potential use as a biomarker or therapeutic target. Non-invasive phase contrast imaging via optical coherence tomography or non-confocal adaptive optics scanning light ophthalmoscopy has allowed investigations into cellular dynamics and morphology. The cells have been variously referred to as microglia, hyalocytes, or ILM macrophages, with no consensus yet reached as to their identity. Here, we employed AOSLO with an improved non-confocal detection scheme to investigate motile immune cells and their relation, if any, to nearby retinal vasculature. Image series were systematically acquired to observe cells over time (30-60 minutes) at different depth planes (9.2 µm separation),

SUBMITTER: Dierickx D 

PROVIDER: S-EPMC12684025 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature