Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children.

ABSTRACT:

Objectives

Growing evidence suggests that vaccines targeting respiratory pathogens have non-specific and broader effects. We aimed to investigate the non-specific effects of respiratory vaccines on acute lower respiratory infection (ALRI) hospitalisations and associated outcomes in children <5 years. We also assessed broader effects of respiratory vaccines, including antimicrobial prescribing patterns.

Design

Systematic review and meta-analysis.

Data sources

We searched online databases including Medline, Embase, CINAHL, Scopus and Clinical Trials.gov from inception to 24 January 2024.

Eligibility criteria

We included human studies involving non-specific/off-target effects of respiratory vaccines (including maternal, infant and childhood vaccines) and excluded

SUBMITTER: Holland C 

PROVIDER: S-EPMC12684133 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature