Immuno-oncologic profiling of renal masses using multiparametric MRI: a pilot study.

ABSTRACT:

Purpose

Preoperative characterization of renal mass malignancy, subtype, and immuno-oncologic pathology could inform and improve tailored management decisions. We examine multiparametric MRI (mpMRI) for (1) sensitivity to immuno-oncologic markers of the tumor immune microenvironment and (2) classification of tumor malignancy, subtype, and grade.

Methods and materials

In a prospective, institutional review board-approved single-center study, 40 patients (13 female/27 males, 60.4±10.7 years) scheduled to undergo surgical management of solid renal masses underwent preoperative 1.5T MRI. This included T1, multi-b-value diffusion-weighted imaging (DWI as intravoxel incoherent motion (IVIM), and apparent diffusion coefficient (ADC)), R2*, arterial spin labeling (ASL), and dynamic

SUBMITTER: Liu MM 

PROVIDER: S-EPMC12684148 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature