Sex and reproductive stage modify the effect of endogenous oestrogens on coronary atherosclerosis in rheumatoid arthritis.

ABSTRACT:

Objective

We explored associations between endogenous oestrogens, coronary atherosclerosis and cardiovascular risk in rheumatoid arthritis (RA). We interrogated whether these relationships varied by sex and menopause and reflected differences in inflammation and lipoprotein functions influencing cell cholesterol homeostasis.

Methods

CT angiography evaluated atherosclerosis in 140 patients without cardiovascular disease from a single-centre observational cohort. Serum estrone and 17-b-oestradiol were measured with Elisa. Serum cholesterol loading capacity (CLC) on macrophages, which enhances atherosclerosis, was measured in THP-1 monocyte-derived macrophages. High-density lipoprotein cholesterol efflux capacity from macrophages via ATP-binding-cassette-A1 (ABCA1-CEC) and G1 t

SUBMITTER: Karpouzas GA 

PROVIDER: S-EPMC12684185 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature