Intranasal dexmedetomidine for perioperative sleep disturbance: a protocol for a systematic review with meta-analysis and trial sequential analysis.

ABSTRACT:

Introduction

Perioperative sleep disturbance (PSD) can adversely affect immunological and cognitive functions, can prolong hospital stays and have long-lasting effects on quality of life, ultimately increasing mortality rates. Unfortunately, PSD is common among surgical patients and can manifest at any stage during surgical care with a high incidence. Owing to the high incidence and severe adverse outcomes of PSD, effective management of PSD is imperative in clinical practice. Intranasal administration of dexmedetomidine is a safe and effective strategy for improving perioperative sleep quality. It is characterised by high bioavailability, a low incidence of adverse events and the avoidance of pain from venipuncture and intramuscular injection. However, this clinical evidence is in

SUBMITTER: Liu D 

PROVIDER: S-EPMC12684196 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature