Association of triglyceride-glucose index and remnant cholesterol levels with liver fibrosis progression and disease severity in patients with non-alcoholic fatty liver disease: a cross-sectional study.

ABSTRACT:

Background

The associations of the triglyceride-glucose (TyG) index and remnant cholesterol (RC) with NAFLD severity (mild, moderate, and severe) and liver fibrosis remain unclear. This study examined these relationships and assessed the impact of TyG\RC on liver fibrosis.

Methods

594356 participants undergoing annual physical and ultrasonic examinations were included. Standardized questionnaires collected clinical data, and venous blood samples were measured for complete blood count, liver function, and metabolic parameters. TyG index and RC values were calculated, and liver fibrosis assessed using the NAFLD fibrosis score (NFS) and aspartate aminotransferase-to-platelet ratio index (APRI). Participants were categorized into TyG and RC levels quartiles (Q1-Q4) to examine th

SUBMITTER: Duan Q 

PROVIDER: S-EPMC12684284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature