Chromatin Regulatory Targets for Anticancer Therapeutics.

ABSTRACT: Chromatin serves to organize and compact the genome but also functions as a signaling hub for the dynamic regulation of transcriptional programs that control cell type specification. The historical discovery that several pro-differentiation anti-cancer agents target chromatin regulatory enzymes buoyed early interest in developing drugs that modulate chromatin structure and function. Chromatin-based drug discovery has since flourished alongside major advances in discovery chemistry and target selection, producing a rich collection of chemical probes, drugs, and drug candidates targeting chromatin regulatory processes. The substantial growth and maturity of this field over the last several decades provides an opportunity to reflect on the successes and failures associated with translating ch

SUBMITTER: Barta PA 

PROVIDER: S-EPMC12684288 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature