Enhancing NMR Signals in Liquids by Fluorine-19 Overhauser Dynamic Nuclear Polarization (DNP) and Hyperpolarization Transfer to Carbon-13.

ABSTRACT: Nuclear magnetic resonance (NMR) plays an essential role in life and material science but suffers from low sensitivity due to the small energy differences it aims to detect. Therefore, techniques that can increase spin polarization, and thus sensitivity, in NMR are gaining tremendous attention. Overhauser effect dynamic nuclear polarization (OE-DNP) can increase multidimensional NMR signals of small molecules in liquid solutions; however, at high magnetic fields, the direct mechanism to ¹³C is site selective, while it is poorly efficient for ¹H. Here, we report OE-DNP hyperpolarization of fluorine-19 (¹⁹F) nuclei at 9.4 T, thus expanding the methodological toolbox of ¹⁹F NMR. Signal enhancements up to ∼20 under steady-state conditions can be used

SUBMITTER: Reinhard M 

PROVIDER: S-EPMC12684320 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature