ATP-Powered Signaling Between Artificial and Living Cells.

ABSTRACT: ATP is the energy currency of life and is overabundant in the tumor microenvironment, where it has been suggested as a target for cancer therapy. We introduce ATP-dissipative delivery of DNA signals from artificial cells to living cells by exploiting an ATP-driven reaction network that transiently ejects DNA Signal strands from the shielded artificial cell interior to the extracellular medium of living cells. We customize the Signal for intracellular uptake or for extracellular instruction using a cytokine-ssDNA chimera that can trigger efficient intracellular downstream signaling programs. Our study discusses details of system design on a timer circuit and artificial cell level, system integration challenges, and how ATP concentrations regulate the transient delivery. The strategy can be

SUBMITTER: Sethi S 

PROVIDER: S-EPMC12684332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature