Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.

ABSTRACT:

Objective

Genetic factors play a substantial role in the etiology of autism and its co-occurrence with other conditions and traits. The primary objective of this study was to clarify the associations between the autism polygenic score and autism diagnosis, autistic traits, and related behavioral and neurobiological traits.

Method

Peer-reviewed studies written in English reporting univariate associations were included. PubMed, Web of Science, PsycINFO, and Scopus were systematically searched on November 2, 2022, and January 6, 2023. The quality of included studies was assessed using the QUIPS tool, systematic review with best-evidence synthesis was applied, and meta-analyses were performed if >5 studies were conducted on similar phenotypes.

Results

Of 72 eligible studi

SUBMITTER: de Wit MM 

PROVIDER: S-EPMC12684455 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature