Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice.

ABSTRACT:

Background

In children born at high altitude, lung development is affected by hypoxia, which can lead to pulmonary hypertension and right ventricular failure. Animal models of postnatal, transient, hypoxia failed to reproduce these conditions seen in children living at high altitude. The aim of this study was to establish a mouse model of pediatric pulmonary hypertension associated with abnormal lung development.

Methods

C57bl/6J mice were exposed to normobaric hypoxia at 11% inspired fraction of oxygen starting on postnatal-days 1 to 4 ("11%-birth"). At age 8 weeks, pulmonary arterial pressure and right ventricular function were assessed using echocardiography and invasive hemodynamics. The physiology and the structure of lung parenchyma and vasculature were assessed throug

SUBMITTER: Zazzeron L 

PROVIDER: S-EPMC12684492 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature