Plasma Phenylacetylglutamine and Cognitive Impairment After Ischemic Stroke.

ABSTRACT:

Background

Phenylacetylglutamine was reported to be associated with ischemic stroke and cognitive performance, but its association with poststroke cognitive impairment (PSCI) remained unclear. We aimed to prospectively investigate the association between plasma phenylacetylglutamine levels and PSCI at 3 months in a multicenter cohort study.

Methods

A total of 617 patients with ischemic stroke were included on the basis of a preplanned ancillary study from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). PSCI was evaluated using the Mini-Mental State Examination scale and Montreal Cognitive Assessment scale. Logistic regression analyses were performed to evaluate the association between plasma phenylacetylglutamine and the risk of 3-month PSCI.

Results

Ac

SUBMITTER: Fei J 

PROVIDER: S-EPMC12684508 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature