Validation of the Hemodynamic Classification System for Hemodynamic-Related Events in Patients With Durable Left Ventricular Assist Devices.

ABSTRACT:

Background

Durable left ventricular assist device (dLVAD) physiology predisposes to right heart failure (RHF) and aortic insufficiency (AI), recently labeled hemodynamic-related events (HDREs). We sought to validate the recently proposed dLVAD Hemodynamic Classification System for HDREs.

Methods

RHF and AI HDREs were adjudicated, staged, and phenotyped on the basis of the Hemodynamic Classification System assessed at 6 months after dLVAD implantation. The primary outcome was a composite of HF hospitalization or cardiovascular death between 6 and 24 months after dLVAD implantation.

Results

Among 183 qualifying consecutive patients with 6-month assessments, RHF HDRE was adjudicated in all cases and AI HDRE in 161 (88.0%). Overall, 53 (29.0%) patients developed an RHF HD

SUBMITTER: Gallone G 

PROVIDER: S-EPMC12684539 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature