Antithrombotic Monotherapy or Combination Therapy for Atrial Fibrillation in Stable Coronary Artery Disease: A Meta-Analysis of Randomized Trials.

ABSTRACT:

Background

In patients with atrial fibrillation and stable coronary artery disease, guidelines recommend oral anticoagulation monotherapy after periods on dual antithrombotic therapy. These recommendations are based on evidence from prematurely terminated randomized controlled trials that were underpowered for bleeding and mortality end points. New data are available, so we conducted a systematic review and meta-analysis to pool the totality of randomized evidence.

Methods

This investigation was preregistered on International Prospective Register of Systematic Reviews (CRD42024590457). Systematic searches and data extraction were performed independently and in duplicate for randomized controlled trials enrolling patients with atrial fibrillation and stable coronary artery di

SUBMITTER: Reddy RK 

PROVIDER: S-EPMC12684541 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature