Antibiotic Exposure and Cardiovascular Disease Risk: A Nationwide Cohort Study.

ABSTRACT:

Background

Antibiotic use may alter gut microbiota, which could be associated with various diseases, including cardiovascular disease (CVD). Accordingly, further epidemiological evidence is needed to clarify the potential risk of CVD associated with antibiotic exposure. We evaluated the association between long-term antibiotic exposure and CVD risk in South Korea.

Methods and results

This nationwide retrospective cohort study used data from the Korean National Health Insurance Service database. A total of 2 159 965 individuals aged 40 to 79 years who had no history of antibiotic prescriptions from 2004 to 2005 were included and followed through December 31, 2021. Antibiotic exposure was defined as the cumulative days of antibiotic prescriptions from 2006 to 2010. The primary

SUBMITTER: Park SJ 

PROVIDER: S-EPMC12684553 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature