Associations of Immune Cell Subsets With Coronary Artery Calcium Incidence and Progression in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

Limited data exist on associations of immune cell subsets with longitudinal changes in subclinical coronary artery disease.

Methods

In the MESA (Multi-Ethnic Study of Atherosclerosis) study, we used a case-cohort approach to explore associations of 28 immune cell subsets measured at baseline (2000-2002) with longitudinal changes in coronary artery calcium (CAC). We examined incident CAC from examination 2 (2002-2004) through examination 5 (2010-2012) in participants with 0 CAC at baseline using multivariable-adjusted Cox regression. In participants with CAC >0 at baseline, we analyzed changes in CAC through examination 5 using multivariable-adjusted linear mixed models. Because no studies have investigated immune cells and longitudinal CAC changes, analyses were c

SUBMITTER: Patel RD 

PROVIDER: S-EPMC12684560 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature