Associations Between Blood Heavy Metal Concentrations and Hypertensive Disorders of Pregnancy in the Japan Environment and Children's Study.

ABSTRACT:

Background

Previous studies reported inconsistent associations between blood heavy metal concentrations and the risk of hypertensive disorders of pregnancy (HDP), potentially due to small sample sizes and variations in exposure levels, timing of blood sampling, and confounding factors. We investigated this association in Japanese women, a population with relatively low metal exposure, to provide a unique perspective in a low-exposure setting.

Methods

We included 88 670 pregnant women, with a mean age of 31.2±5.1 years, enrolled in the Japan Environment and Children's Study. We examined the associations between concentrations of heavy metals (lead, cadmium, and mercury) in blood collected during the second or third trimester and HDP, using multiple logistic regression under a

SUBMITTER: Morimoto N 

PROVIDER: S-EPMC12684563 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature