Validation of a 0-/2-Hour High-Sensitivity Cardiac Troponin Algorithm for Suspected Acute Coronary Syndrome in the Emergency Department.

ABSTRACT:

Background

We implemented a hs-cTnI (high-sensitivity cardiac troponin I)-based algorithm for emergency department (ED) evaluation of possible non-ST-segment-elevation acute coronary syndrome within an integrated health system (Kaiser Permanente Northern California).

Methods

Retrospective study of adult (18+ years) ED encounters for chest pain/discomfort with hs-cTnI testing (Access hsTnI, Beckman) at 21 medical centers between January 1, 2023 and June 30, 2024, excluding ST-segment-elevation myocardial infarction. The primary outcome was 30-day myocardial infarction or death. Sensitivity, specificity, negative predictive value, positive predictive value, and likelihood ratios were reported, with subgroup analyses by age, sex, coronary artery disease, chronic kidney disease,

SUBMITTER: Mark DG 

PROVIDER: S-EPMC12684567 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature