Presence of Clonal Hematopoiesis and Cardiac Events After Allogeneic Stem Cell Transplantation.

ABSTRACT:

Background

Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been associated with serious cardiotoxicity, including atrial fibrillation (AF) and other cardiac events. In preclinical models, posttransplant clonal hematopoiesis (CH) frequently parallels or precedes clinical AF, yet whether this is seen in patients or has implications for cardiotoxic risk in long-term follow-up is unknown.

Methods

Leveraging consecutive patients treated with alloHSCT, genotyped using deep-amplicon sequencing to detect the presence of CH, we assessed the development of new (incident) AF, by CH status. Secondary outcomes were the occurrence of major adverse cardiac events, defined as heart failure, myocardial infarction, AF, symptomatic ventricular arrhythmias, and cardiovascular

SUBMITTER: Quartermaine C 

PROVIDER: S-EPMC12684579 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature