Risk of Cardiovascular Disease With Co-Occurring Covert Brain Infarction and Unrecognized Myocardial Infarction.

ABSTRACT:

Background

Covert brain infarction (CBI) increases the risk of atherosclerotic cardiovascular disease (ASCVD), but optimal clinical management is uncertain. To enable tailored preventive measures, we aimed to determine whether the co-occurrence of CBI with unrecognized myocardial infarction (UMI) identifies a subgroup at especially high risk of ASCVD.

Methods

We included participants from the population-based Rotterdam Study, who were aged ≥45 years and without a history of stroke, transient ischemic attack or myocardial infarction. Participants underwent electrocardiography and brain magnetic resonance imaging between 2006 and 2012 and were followed up for first-ever ASCVD (ie, composite of ischemic stroke and recognized myocardial infarction). We used Cox models adjusted f

SUBMITTER: Box CVJ 

PROVIDER: S-EPMC12684583 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature