From Vessels to Cognition: Glymphatic Alterations Following Hemorrhage in Cerebral Amyloid Angiopathy Are Associated With Small Vessel Disease Burden.

ABSTRACT:

Background

Cerebral amyloid angiopathy-related hemorrhage is associated with both cerebral small vessel disease (CSVD) pathology and long-term cognitive decline. The role of glymphatic dysfunction in mediating this relationship remains unclear.

Methods

A total of 111 participants (64 patients with cerebral amyloid angiopathy-related hemorrhage, 47 healthy controls) underwent 7T magnetic resonance imaging at a stable postintracerebral hemorrhage stage. Imaging analyses included the Analysis Along the Perivascular Space (ALPS) index derived from diffusion tensor imaging, volumetric quantification of perivascular spaces, and choroid plexus segmentation. Hierarchical regression assessed group differences and associations with CSVD markers and cognition. Mediation analyses tested

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12684585 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature