GATA2 Mediates Macrophage Proliferation During Atherosclerosis.

ABSTRACT:

Background

Atherosclerosis is fueled by the buildup of lipid-laden macrophages within the vascular intima. These macrophages are derived from monocytes that are recruited from the circulation into the developing lesion, where they proliferate and differentiate into macrophages, with local proliferation generating most of these macrophages. However, the signals and transcriptional events driving the proliferation of atheroma macrophages remain poorly understood.

Methods

Transcriptomic and histological analysis of human plaque spanning a range of disease severity and in vitro models of macrophage function was conducted.

Results

Transcriptomic analyses identified a subpopulation of macrophages that expressed the hematopoietic transcription factor GATA2. These GATA2-expre

SUBMITTER: Aktar A 

PROVIDER: S-EPMC12684594 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature