Association of Free Fatty Acids With Long-Term Adverse Outcomes in Patients With Premature Myocardial Infarction: A Prospective Cohort Study.

ABSTRACT:

Background

The dose-response relationship and independent prognostic value of free fatty acids (FFA) for major adverse cardiovascular events (MACE) in patients with premature myocardial infarction are not well established. This study aimed to evaluate the impact of FFA levels on long-term outcomes and their combined effects with inflammatory markers, obesity, and insulin resistance.

Methods

This prospective cohort study enrolled 1168 consecutive patients with premature myocardial infarction admitted to the coronary care unit ward of Tianjin Chest Hospital from March 2017 to December 2024. Participants were categorized into 4 groups (Q1-Q4) by baseline FFA quartiles. Over a median follow-up of 2.83 years (interquartile range, 2.58-3.10), the primary end point was MACE. Cox pr

SUBMITTER: Wang J 

PROVIDER: S-EPMC12684601 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature