Association of Ezetimibe and Statin Combinations With Recurrent Ischemic Stroke: A Nationwide Study With Dual Design.

ABSTRACT:

Background

Statin is recommended for patients with ischemic stroke (IS) to lower low-density lipoprotein cholesterol. Although combining statin with ezetimibe further reduced low-density lipoprotein cholesterol, its impact on IS recurrence has varied by statin type.

Methods

We used 2 study designs-a retrospective cohort and a case-control study-using the Korean Health Insurance Review and Assessment database. Patients hospitalized for IS between July 2017 and July 2021 who were treated with atorvastatin or rosuvastatin were included. The cohort study compared recurrent IS risk between ezetimibe users and nonusers, using 1:1 propensity score matching for baseline characteristics. The case-control study assessed ezetimibe use between recurrent cases with IS and age-, sex-, ind

SUBMITTER: Lee DH 

PROVIDER: S-EPMC12684614 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature