Body Mass Index Modifies Associations Between Diet Quality and Circulating Metabolites: The CARDIA Study, 2005 to 2006.

ABSTRACT:

Background

Obesity perturbs metabolism, resulting in differential diet-disease associations, but metabolic pathways that differ by obesity remain unclear. We investigated whether cross-sectional associations between metabolites and diet quality differ by obesity status in 2832 participants in the CARDIA (Coronary Artery Risk Development in Young Adults) cohort study.

Methods

We used untargeted metabolomics (7255 metabolite peaks) and an a priori diet quality score (APDQS) to (1) compare model accuracy and prediction, stratified by body mass index (BMI); (2) assess modification of APDQS-metabolite associations by BMI in linear regression models; (3) identify pathways with differential metabolic activity by BMI; and (4) assess the strength and direction of associations with id

SUBMITTER: Hullings AG 

PROVIDER: S-EPMC12684625 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature